One of the major steps in formulation development activity is the development of film coating formulation and process. Formulation and development scientist should understand the critical aspects associated with different kind of coating technique and process. The decision regarding the coating technology is very critical. It is very important to use the most optimized coating formulations in order to get the best results. Various film forming polymers are used to form the coat around the drug for different purposes. Fluidized bed processing is widely used as it is ideal for a wide range of both heat sensitive and heat resistant products.. Difficulties arise with the large number of variables involving in the fluidized bed coating process. Various variables affect the quality of drug layering. In our research work, we used Box-Behnken design to statistically optimize the selected processing parameters and evaluate the main effects, interaction effects and quadratic effects of the processing parameters on the drug layering. From our research work we found that as the fluidization pressure was increased, the drug content was also increased. As atomization pressure and feed rate increases, the drug content decreases.
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